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Claiblyabaphy by Claiblyabaphy on 2011-01-15 00:54:48

[url=http://amitriptyline.info/amitriptyline-interact.html]Amitriptyline HCl[/url] — Amitriptyline is demethylated in the liver to nortriptyline, which has antidepressant effects. It is approximately 95 percent protein bound, and has a t 1/2 of 9 to 25 hours. Like imipramine, it potently blocks reuptake of norepinephrine and serotonin. It has higher affinities for histaminic and muscarinic receptors than imipramine; compared with other cyclic antidepressants, amitriptyline is highly sedating and anticholinergic. The usual starting dose of amitriptyline is 25 mg, typically given at bedtime. Therapeutic doses are generally in the range of 100 to 300 mg daily, but many patients find it difficult to reach these doses due to sedation. There is disagreement about the reliability of amitriptyline blood levels in predicting therapeutic response, although response may correlate with blood levels of amitriptyline plus nortriptyline (its active metabolite) greater than 95 to 160 ng/mL. [url=http://mirtazapine.info/]Mirtazapine[/url] is an antidepressant with a novel mechanism of action. The cell receptors that regulate production of norepinephrine and serotonin are blocked so that the neurotransmitters continue to be produced even when their concentrations might normally shut down production by the cell. In addition, mirtazapine has 5HT2 and 5HT3 blocking action that may make it useful as a coanalgesic and antiemetic; clinical trials are underway to evaluate its potential in these two important areas for cancer patients. Mirtazapine also appears to block the H1 receptor in the CNS. It has some sedative side effects and stimulates appetite, side effects that may be very useful in some patients. It can be administered as a single dose at bedtime..

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